To report an adverse event or product quality complaint, call 1-877-TAKEDA-7 (1-877-825-3327)
To report an adverse event or product quality complaint, call 1-877-TAKEDA-7 (1-877-825-3327)
Not actual patients.
EoE is characterized by eosinophilic inflammation, which is thought to be triggered by exposure to aero- or food allergens, and can lead to esophageal dysfunction.1,2
The prevalence of EoE in the US is increasing.3,4 The estimated prevalence of EoE in the US is 147.4 cases per 100,000 individuals.5 EoE is often accompanied by other comorbidities, and has a strong association with atopic disease.1,6,7 Clinicians should maintain a high index of suspicion of EoE, regardless of age, race or sex; however, EoE is approximately twice as common in men vs women and more common among White people, with symptoms varying by age.8
The pathophysiology of EoE involves the production of pro-inflammatory cytokines that promote the recruitment and proliferation of immune effector cells, such as eosinophils, at the site of inflammation. This chronic inflammation, localized to the esophagus can disrupt normal epithelial integrity.2,9,10 If left untreated, the disease can progress to a fibrostenotic phenotype with esophageal remodeling and dysmotility.1,11,12
The diagnosis of EoE is dependent on three criteria which include symptoms of esophageal dysfunction, ≥ 15 eos/hpf on a histologic examination of the esophageal biopsy, and an evaluation for non-EoE disorders that cause or potentially contribute to esophageal eosinophilia.4 A diagnosis of EoE is not reliant on prior response to proton pump inhibitors (PPIs).4 The presence of other atopic diseases, including immediate-type food allergies, asthma, atopic dermatitis, and allergic rhinitis, should increase the suspicion of EoE.4 Furthermore, patients may develop adaptive eating and avoidance behaviors as a coping strategy for the symptoms of EoE, which can make symptom severity difficult to discern and result in diagnostic delays.4 These behaviors can be assessed using the IMPACT acronym, which includes imbibing fluids, modifying foods, prolonging mealtimes, avoiding hard-textured food, chewing excessively, and turning away tablets/pills.4 Endoscopic evaluation using the EREFS is strongly recommended to characterize the key features of EoE by severity, which include edema, rings, exudates, furrows, and strictures.4
The symptoms and impact of EoE can vary by age.1,13 Infants and toddlers with EoE may experience vomiting, food refusal, choking with meals, and sleep disturbances. Children may experience dysphagia, choking and gagging with certain foods, food impactions, pain, nausea and vomiting, sleep disturbances, and decreased appetite. Adults may report dysphagia, food impaction, food avoidance, intractable heartburn, regurgitation, and chest pain. Surveys of patients with EoE suggest their greatest concerns relate to difficulty swallowing and the overall impact on eating.14,15 Symptomatic improvement has been shown to be a key endpoint of therapy.16,17
This resource provides information on Takeda medications available in the Eosinophilic Esophagitis category and is not intended to represent a complete list of therapeutic options.
(budesonide oral suspension)
This is not intended to be a comprehensive resource of all congresses and congress materials across therapeutic and disease areas. Congress materials may include information about investigational use(s) of compounds/products that are not approved for use by the U.S. Food and Drug Administration (FDA) and/or are inconsistent with the Prescribing Information. Takeda does not recommend the use of any Takeda product beyond the approved labeling. Any decisions regarding the usage of a Takeda product beyond the approved labeling are left to the discretion of the healthcare professional. Takeda makes no representations about whether investigational compounds or unapproved uses will be approved by the FDA.
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Watch videos focused on Eosinophilic Esophagitis (EoE).
Learn more about Eosinophilic Esophagitis (EoE), a chronic immune-mediated condition.
Find materials to help foster a deeper understanding of Eosinophilic Esophagitis (EoE).
Learn more about Eosinophilic Esophagitis (EoE), a chronic immune-mediated condition.
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